is a waxy fat that is present in all human beings. Two sources contribute
to the amount of cholesterol in the human body. First, the liver
manufactures about 80 percent of it. Second, people consume it by eating
animal products such as meat, eggs and dairy products. Cholesterol is
carried through the bloodstream by certain proteins (apolipoproteins).
When these proteins wrap around cholesterol and other types of fats
(lipids) to transport them through the bloodstream, the resulting
"packages" are called lipoproteins
There are four different
types of lipoproteins that carry cholesterol through the bloodstream: 1)
High-Density lipoproteins(HDL) associated with "good"
cholesterol, 2) Low-density lipoproteins (LDL) associated with
"bad" cholesterol, 3) Very-low-density lipoproteins (VLDL),
which are associated with "very bad" cholesterol, 4)
Triglycerides which only carry a small percentage of cholesterol.
The National Cholesterol
Education Program classifies total cholesterol levels as follows:
- Less than 200, desirable,
- Between 200 and 239, borderline to high,
- Over 240, High.
- Below 40 poor (High risk for
Coronary Heart Disease)
- 40 to 60 mid range
- Above 60 good (Low risk for Coronary
- Below 100 optimal
- 100-129 near optimal
- 130-159 border line high
- 160-189 high
- 190 or above very high
- Below 150 normal
- 150-199 borderline high
- 200-499 high
- 500 and above very high
Impotency and Cholesterol
In a totally unrelated development (unrelated to aging, that
is), National Institute of Aging supported scientists from the University of
South Carolina have found yet another compelling reason to avoid cholesterol.
Men with lower
blood cholesterol or higher amounts of the beneficial high-density lipoprotein (HDL)
cholesterol may be less likely to develop erectile dysfunction or impotence. According to the researchers, atherosclerosis (hardening of the
arteries), which may impede blood flow to and from the penis, is one primary
cause of impotence. While a positive link between blood cholesterol and
atherosclerosis, the association between cholesterol and impotence has only been
suggested until now.
is a revolutionary formula that helps to reduce LDL (bad) cholesterol while increasing HDL (good) cholesterol.
Cholestrien contains a unique combination of natural ingredients that are highly recommended in maintaining cholesterol levels thereby helping to reduce high blood pressure, anxiety and heart attacks.
The effect of Cholestrien is partially attributed to the presence of HMG-CoA reductase inhibitors, enzymes in the liver that control the amount of cholesterol produced in the liver. It has been hypothesized that relatively high concentrations of unsaturated fatty acids and other natural compounds found in Cholestrien
may work in concert with HMG-CoA reductase inhibitors to provide additional health
Red Yeast Rice
Red Yeast Rice has been used in China for centuries as both a food and as a medicinal substance. It is made by fermenting a type of yeast called Monascus purpureus over red rice. In Chinese medicine, red yeast rice is used to promote blood circulation, soothe upset stomach, and invigorate the function of the spleen, a body organ that destroys old blood cells and filters foreign substances. In addition, this dietary supplement has been used traditionally for bruised muscles, hangovers, indigestion, and colic in infants. Recently, it has been discovered that red yeast rice contains substances that are similar to prescription medications that lower cholesterol. There is also growing interest in evaluating red yeast rice for use as a natural food dye and/or preservative.
The mechanism of the hypolipidemic activity of red yeast rice is not entirely clear. The possible hypocholesterolemic activity of red yeast rice can be accounted for, in part, by the presence of HMG-CoA reductase inhibitors, especially monacolin I (lovastatin, mevinolin) and its corresponding beta-hydroxy acid, monacolin II. Lovastatin is converted in the body to its corresponding beta-hydroxy acid, which is the form that inhibits HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, which is an early and rate limiting step in cholesterol biosynthesis. Lovastatin is known to lower plasma total cholesterol, low-density lipoprotein cholesterol (LDL-C), the total cholesterol/HDL-C ratio and the LDL-C/HDL-C ratio. Lovastatin may also produce a modest increase in HDL-cholesterol and modest decreases in VLDL-C and triglyceride levels in some.
LDL is formed from VLDL and is principally catabolized via the high affinity LDL receptor. Lovastatin's mechanism in lowering LDL appears to also involve reduction of VLDL-C levels and upregulation of the LDL receptor, resulting in reduced production of LDL-C, as well as increased catabolism of LDL-C.
Policosanol is a nutritional supplement extracted
from sugar cane wax. Its main component is a mixture of higher primary aliphatic
alcohols known as octacosanol. The mixture has been shown to lower cholesterol
in animal models, healthy volunteers, and patients with type II
Policosanol has been shown to be equally effective
as Zocor® or Pravachol® at lowering low-density
lipoprotein (LDL) and total cholesterol levels. Additionally, in a study with 85
patients, policosanol was shown to produce significant cholesterol-lowering
effects without causing any serious adverse reactions
in various short- and long-term studies. The profound cholesterol-lowering
benefits of policosanol may be apparent in as little as 6 to 8 weekswith
modest, beneficial effects resulting after this time period. According to a
recent scientific review, 20mg of policosanol per day for 8 weeks yields the
following average results:
Lower total cholesterol levels by 21%
Lower LDL levels, or bad cholesterol, by 29%
Increase high-density lipoprotein (HDL) levels, or
good cholesterol, by 15%
Secondary Cardiovascular Benefits
Not only has policosanol been demonstrated as an effective lipid-lowering supplement, but it has also been shown to improve other predictive markers of cardiovascular risk. By supporting the function and integrity of the endothelium (blood vessel lining), policosanol may assist in the prevention of atherosclerosis. In addition, policosanol has also been shown to reduce blood pressure levels, which may be of particular importance in older populations wherein concomitant hypercholesterolemia and hypertension are more frequent. Specifically, policosanol has been shown to provide the following additional cardiovascular benefits:
Prevent Lipid Peroxidation of LDL. Oxidized LDL cholesterol can contribute to hardening of the arteries. Policosanol was shown to prevent LDL oxidation in vitro, suggesting it may support blood vessel elasticity and flexibility.
Inhibit Smooth Muscle Cell Proliferation. Accelerated smooth muscle cell proliferation is thought to be a primary factor in the development of atherosclerotic plaque. In experimental models, policosanol was shown to significantly reduce smooth muscle cell proliferation, suggesting it may have a protective effect on the arterial wall.
Inhibit Platelet Aggregation. Excessive platelet
aggregation can lead to the formation of blood clots and increased
cardiovascular risk. Research on humans suggests that policosanol inhibits
platelet aggregation, possibly by reducing the formation of thromboxane A2a
potent inducer of platelet aggregationand increasing the production of
prostacyclin, which is a potent inhibitor of platelet aggregation.
May Help to Lower Blood Pressure. Elevated blood pressure and cholesterol levels often coexist. Human research suggests that policosanol may help to lower systolic blood pressure levels, which may be of particular importance in the elderly.
Guglipid is derived from the mukul myrrh tree, a small thorny tree 4 to 6 feet tall, that is native to Arabia and India. The tree remains without any foliage for most of the year. It has ash colored bark, and comes off in rough flakes, exposing the underbark, which also peels off. The tree exudes a yellowish resin called gum guggul or guggulu, that has a balsamic odor. This resin is used for medicinal purposes.
Ketone fraction that is extracted from the resin contains the most potent cholesterol lowering components. This is composed of C21 or C27 steroids, with the major components being Z- and E-guggulsterone. Guggul contains resin, volatile oils, and gum. The extract isolates ketonic steroid compounds known as guggulsterones. These compounds have been shown to provide the lipid-lowering actions noted for guggul. Guggul significantly lowers serum triglycerides and cholesterol as well as LDL and VLDL cholesterols (the "bad" cholesterols). At the same time, it raises levels of HDL cholesterol (the "good" cholesterol). Guggul has also been shown to reduce the stickiness of platelets-another effect that lowers the risk of coronary artery disease.
Guggul exhibits a cholesterol lowering
ability unlike any other natural substance. In human trials, using gugulipid,
the cholesterol levels dropped 14 to 27 percent in a 4 to 12 week period while
the triglyceride levels dropped from 22 to 30 percent. This guggul has great
effect in preventing heart atherosclerosis, or narrowing of the arteries.
The information and procedures
contained herein is not presented as medical advice nor should it
be used as a substitute for consultation with a qualified health
care practitioner. The information contained herein has not been
evaluated by the Food and Drug Administration. These products and
the information set forth herein are not designed to diagnose,
treat, cure or prevent any disease nor should any information
contained herein be read as prescribing any specific remedy or
guaranteeing any specific result. We are not responsible for any
adverse effects or consequences resulting from the use of any of
the suggestions preparations, or procedures discussed herein. All
matters pertaining to your physical health should be supervised by
a health care professional.